Differin Acne Retinoid Treatment Gel, 0.1% Adapalene, 45g Pump

This is officially my second purchase, and I can confidently say it’s earned a permanent spot in my routine. It definitely doesn't work overnight, so you have to be patient with it. However, with consistent daily usage, I started noticing a real difference in my skin texture and overall clarity. It significantly minimized the stubborn acne marks left behind by my closed comedones. If you're willing to stick with it through the initial adjustment phase, the long-term results are completely worth it!

Have had a nasty ongoing cyst behind my ear that was the size of a hazelnut, fpr months! I drained it a few x with sterile needles and such (pls don't do that) but always came back. I started applying this on it once a day. After 4 days, it drained on it's own. After cleaning it well, i applied a bandaid for 1 day, then resumed this product. Area is now completely dried out and flat. Just a few days away from being 100% resolved. I also apply it to hormonal acne as spot treatment and works pretty fast. Only place i really did get pretty dry was my chin area but with face oil, it was manageable.

My go-to acne treatment for years I’ve been using this Differin acne treatment for more than three years, and it has become one of my go-to products for managing breakouts. I mainly use it at night and apply a small amount to areas where I’m experiencing breakouts. Over time, I’ve been very happy with how it helps keep my skin clearer and manage occasional acne. A little goes a long way, so one tube lasts quite a while when used as directed. I would recommend starting slowly if you’re new to retinoids, since they can cause dryness or irritation while your skin adjusts. I also avoid applying it too close to my eyes and other sensitive areas. After using it consistently for more than three years, I can honestly say this is one acne treatment I keep coming back to. It has worked well for me and is definitely worth considering if you’re looking for an acne treatment.

This acne treatment gel is one of the best skincare products I've used. It’s powerful yet gentle, and it really delivers on clearing breakouts and preventing new ones. 🔹 Clears Acne & Helps Prevent New Breakouts It works deep into pores to target acne at the source — rather than just drying out existing pimples, it helps stop new ones from forming. After a few weeks of use, I noticed fewer breakouts and smoother skin overall. 🔹 Gentle Enough for Sensitive Skin Even though it’s a retinoid and highly effective, the formula is water-based, oil-free, and non-comedogenic. It didn’t irritate my skin or cause excessive dryness — you get the power of a prescription-strength product with a surprisingly gentle finish. 🔹 Improves Skin Texture and Reduces Acne Marks Over time, my skin tone looked more even, and old blemishes faded faster. It not only treats active acne but also helps with discoloration and overall smoothness. 🔹 Easy Daily Use & Real Results It integrates easily into a nightly skincare routine. Once applied, it absorbs quickly and layers well under moisturizer. Within a few weeks, skin felt clearer and healthier — you can actually see the difference on breakouts, tone, and texture. ✅ Pros: Powerful acne treatment that works deep in pores Helps prevent future breakouts instead of just treating existing ones Gentle enough for sensitive/acne-prone skin Improves skin texture and marks over time Easy to use daily and delivers real results ❌ Cons (minor): Skin may feel slightly dry at first — best to pair with a good moisturizer Overall: If you struggle with acne or frequent breakouts, this gel is a game-changer. Effective, gentle, and noticeable results — a solid 5-star product that I’d recommend without hesitation.

I’ve been using Differin gel to help with breakouts, and it has noticeably improved my skin over time. It works well, but it can make my skin feel dry, so I recommend using a good moisturizer along with it.

This is a magical gel; over time, it helped me get rid of the "goosebumps" texture on my face—something I had been trying to eliminate for years! I highly recommend it. It doesn't work instantly, so be patient and wait for the results.

Seriously, I never stop to rate unless I need to warn people if scams or whatever...but I am so happy that I tried this product after so long of feeling hopeless to try to treat Milia on my chin that would not go away. I read an article about adapalene and figured i would try as the gel wasn't that expensive and it was a Dermatologist who recommended that treatment. So I have put it on 3x in 3 days and this morning, not expected to see anything change, but after my shower I dabbed a tiny bit on the spot continues to brush my hair and...it came out! No pinching no rubbing at all just opened the pore and released it! Seriously want to share for anyone experiencing it! Give it a few days =) 💯 worked!

I am writing this review after being on Differin for 1 year. I started Differin just a few months before my 45th birthday. I had never really dove real deep into a skincare routine before. Just washing my face and using a basic retinol cream. You can see from my photos that I definitely had deep wrinkles, fine lines, uneven tone, texture, and dry skin especially under my eyes, occasional breakouts, blackheads, large pores, and some scars from popping pimples. I still don’t have a real complicated skin care routine now. I’m just starting to add more active treatments, so the results in the photos are primarily Differin and moisturizer. I have to say what gets me the most are my under eyes and lips in these photos. Because retinoids migrate up to 2 inches when absorbed, I didn’t really use a separate treatment product on my eyes or lips. Just a cream and lip balm. I got the idea to use Differin AKA Adapalene from watching Dr. Maren Locke (The Budget Dermatologist) on YouTube. She said it’s a great budget option for a powerful retinoid that’s prescription strength when you’re dealing with wrinkles but still breakout. If you haven’t seen her videos I highly recommend you check them out. Especially the ones about Differin and how to introduce it to your skin. I followed her instructions to a T and I’m glad I did! Don’t think that if you’ve used retinol for a while you’re safe from irritation. I wasn’t, this stuff is Retinoic Acid just a little more gentle than Tretinoin. It does not have to make any conversions in your skin before it gets to work. Unlike retinol- 2 conversions and retinal- 1 conversion. It is strong!! And it absolutely works for pimples and everything else I mentioned above. I do not regret trying this and giving my skin the time it needed to adjust completely (it took about 8 wks). During your adjustment period I strongly suggest you put aside anything with Hyaluronic Acid in it. It will pull the Differin deeper into your skin and can increase irritation. Also maybe lay off other actives if you can. Sunscreen is an MUST and my skin did not like chemical sunscreens during this period. I had redness during this time and increased sensitivity to the sun. I didn’t have too much peeling but my skin definitely liked moisturizer. Here’s what I used to help adjust and keep the irritation low and bearable. Morning: Vanicream gentle facial cleanser (pump), La Roche-Posay Toleraine Double Repair Moisturizer, Australian Gold mineral tinted sunscreen spf 50. Night: same cleanser, then I used the sandwich method for applying the differin. I used the same moisturizer, applied the differin, then applied more moisturizer. Doing this really helped me! My result photos: I’m gonna give full disclosure so you can make an informed decision about this product. My before photo was taken during the day, indoors with the light on. I was also about 30 pounds heavier than I am now. Yay! My 1 year later photos I am almost 46, they were taken at night but indoors with the light on. My skin looks red but it’s not. That’s just the lighting difference. Both photos are just straight up my skin, up close and personal lol. I’m not wearing makeup nor had I done my nighttime routine yet. I also don’t have any lip balm on. It’s just me. Before picture is on the left and 1 year on the right. My forehead photo before is on the bottom and 1 year on the top. I’m also going to try to find an adjustment period photo. It won’t be split and I am super red. I will without a doubt continue to use this as my retinoid everyday. The only way I’d stop is if I was able to get Tretinoin. THIS STUFF WORKS and it’s AFFORDABLE!

I used it only for 3 days and it dried my skin so much that I had red patches. Stopped using immediately