how to use 2 boards to get 8 channels? are the I2C addresses configurable?

Yes, these boards are addressable. You short ADDR pin to Vcc, or GND or SDA or SCL to program board address. You can use maximum 4 of these boards, total 16 single ended channels or 8 differential. See 5th image on Amazon page for these boards or go to Adafruit website for more details. BTW be aware of knock off ICs. Many boards I worked with were advertised and sold as 16 bit but actual board worked as 12-bit only. So if you work with these and have problems getting 16-bit resolution...you have been forewarned :). Good luck.

Can this read differential voltages higher than the input voltage? I want to read cell voltages in a 48v battery pack

If you use a voltage divider with two resistors you can. Search google voltage divider. But you lose a little bit accuracy. There are good videos on YouTube about this ADS1115 explain all that.

Could I use this to read voltages from 0 to 100 mV from a sensor?

Yes, you can read voltages from 0 to 5V. Be careful not to apply more than 5V or you will destroy the IC.

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HiLetgo 3pcs ADS1115 16 Bit 16 Byte 4 Channel I2C IIC Analog-to-Digital ADC PGA Converter with Programmable Gain Amplifier High Precision ADC Converter Development Board for Arduino Raspberry Pi

Product ID: 152293523

⚡2.0V-5.5V wide voltage range

🔌4-channel multi-input versatility

🔢16-bit high precision ADC

87.40 DT

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Description

⚙️ Elevate your DIY projects with precision and power – don’t get left behind!

MULTI CHANNEL MASTERY - Seamlessly monitor up to 4 inputs or 2 differential signals with flexible channel configurations.
PLUG PLAY I 2 C INTERFACE - Effortless integration with Arduino and Raspberry Pi via I2C for rapid prototyping.
ENERGY EFFICIENT SMART MODE - Single-shot mode with auto shut down conserves power without sacrificing performance.
PROGRAMMABLE GAIN AMPLIFIER - Boost weak signals up to 16x for enhanced sensitivity and dynamic range.
PRECISION THAT POWERS INNOVATION - Experience ultra-accurate 16-bit analog-to-digital conversion for flawless data capture.

The HiLetgo ADS1115 is a compact, high-precision 16-bit ADC converter breakout board featuring 4 input channels and a programmable gain amplifier. Designed for microcontrollers lacking analog inputs, it supports a wide voltage range (2.0V-5.5V) and communicates via I2C, making it ideal for Arduino and Raspberry Pi projects requiring accurate analog signal measurement with low power consumption.

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