Product Name Tretinoin Synonyms All-trans retinoic acid, ATRA, Aberela, Airol, Renova, Atralin, Retin-A, Avita, Retacnyl, Refissa, or Stieva-A, Vesanoid CAS No. 302-79-4 Molecular Weight 300.44 Formula C20H28O2 Â Biological activities Tretinoin is a derivative of vitamin A. Tretinoin is often used as a form of acne treatment.Tretinoin is also used to treat and reduce the appearance of stretch marks by increasing collagen production in the dermis.Tretinoin is also used to treat acute promyelocyticleukemia.[1]Tretinoin prevents the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy.[2] Â Protocols In vivo: Tretinoinis dissolved in an ethanol:propylene glycol vehicle.[2] Â References [1] Huang ME, et al. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia.Blood. 1988, 72(2):567-572. [2] Schwartz E, et al. In vivo prevention of corticosteroid-induced skin atrophy by tretinoin in the hairless mouse is accompanied by modulation of collagen, glycosaminoglycans, and fibronectin.J Invest Dermatol. 1994, 102(2): 241-246. Â
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