When adding new fish or changing water do I have to use the entire 5ml/10gallon rule ?

I would do it if it were me. Most fish come from pet stores that are severly overstocked and under maintained so they are already stressed when you bring them home. Add to that the fact that they are being moved for the umpteeth time and they can use all the help they can get. I will say that I do use half doses when I move my fish from one tank to another only because they tanks are well maintained and the water parameters are pretty much the same so the fish are less stressed. Other people may have different opinions but this is my process and it works for me. I have four tanks. I have a 125, 90, 55 and a 40. I have been in the hobby for over 15 years. I also keep two aquatic turtles as well. Hope this helps.

any views on this product versus API's stresscoat?

Different products, API is a water conditioner, stressguard is an antiseptic for open wounds, cuts. I used StressGuard occasionally and API on water changes.

Do you have to remove purigen from your filter

No. Generally Seachem products are safe to use with other Seachem products. Normal filters, nor purigen filters have to be removed when using Stress Guard. It's perfectly safe.

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StressGuard 500 mL / 17 fl. oz.

Product ID: 3983083

Details

Brand
Seachem
Item Form
Liquid
Item Weight
1.2 pounds
Liquid Volume
500 ml
Unit Count
16.9 Fluid

💧Effective dose: 2.5–5 mL per 10 gallons daily

⚗️pH neutral formula (7.0) safe for reefs & invertebrates

🛡️Premium slime coat protection

156.69 DT

Duties & taxes included

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Description

🛡️ Protect your aquatic friends like a pro — stress-free, science-backed care!

TARGETED WOUND CARE - Binds to exposed proteins to promote rapid healing and infection prevention
EASY PRECISE DOSING - Use 1/2–1 capful per 40L daily, with safe double dosing option
STRESS LESS HEAL FASTER - Reduces fish stress and ammonia toxicity during handling and transport
SAFE FOR SENSITIVE ECOSYSTEMS - pH neutral formula ensures no disruption to reef or planted tanks
SCIENTIFICALLY BACKED HOBBYIST APPROVED - Trusted by aquarists for over 30 years with proven performance

Seachem StressGuard is a premium aquarium conditioner designed to reduce fish stress and ammonia toxicity while promoting wound healing through a protein-binding colloidal agent. Its pH-neutral formula (7.0) ensures safe use in reef and planted tanks, making it ideal for both hobbyists and professionals seeking reliable, science-driven fish care. Trusted for over 30 years, StressGuard supports healthier, happier fish during transport and handling.

Specifications

ASIN	B001F0KX06
Allergen Information	Gluten Free
Best Sellers Rank	#6,059 in Pet Supplies ( See Top 100 in Pet Supplies ) #38 in Aquarium Water Treatments
Brand	Seachem
Brand Name	Seachem
Customer Reviews	4.8 out of 5 stars 4,119 Reviews
Global Trade Identification Number	00000116052306
Included Components	Seachem StressGuard 500ml
Item Form	Liquid
Item Type Name	Aquarium conditioner
Item Weight	1.2 pounds
Liquid Volume	500 ml
Manufacturer	Seachem Laboratories, Inc.
Manufacturer Part Number	523
Model Number	523
Number of Items	1
Pet Type	Fish
Target Species	Fish
UPC	000116052306
Unit Count	16.9 Fluid Ounces

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