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🐾 Stay ahead of fleas—because your dog deserves the best defense!
Advantage II XL Dog Topical Flea Treatment & Prevention is a vet-recommended, fragrance-free topical solution designed for dogs over 55 lbs and 7 weeks old. It kills fleas at all life stages within 12 hours and provides 30 days of continuous protection. Easy to apply, waterproof after 24 hours, and available over the counter, it ensures your large dog stays flea-free and comfortable all month long.














| ASIN | B004QRJJF0 |
| Active Ingredients | Imidacloprid, Pyriproxyfen |
| Age Range Description | 7 weeks and older |
| Allergen Information | Allergen-Free |
| Best Sellers Rank | #1,963 in Pet Supplies ( See Top 100 in Pet Supplies ) #15 in Dog Flea Drops |
| Brand | Advantage |
| Brand Name | Advantage |
| Customer Reviews | 4.5 out of 5 stars 6,828 Reviews |
| Dog Breed Size | Large |
| Global Trade Identification Number | 00724089203212 |
| Item Form | Drops |
| Item Type Name | Topical |
| Item Volume | 24 ml |
| Item Weight | 2.56 ounces |
| Manufacturer | Elanco US Inc |
| Manufacturer Part Number | 86336669 |
| Model Number | 86336669 |
| Scent | Unscented |
| Scent Name | Unscented |
| Target Species | Dog |
| UPC | 724089203212 |
| Unit Count | 6 Count |
| Volume | 24 ml |
D**D
Very effective
Love that it’s safe for pregnant dogs and small puppies. We use the product on all our dogs and bought the cat version for our cats. No problems with fleas. Easily applied.
H**H
Great product, great value- fleas are gone!
I've been using Advantage for flea control for several years, and Amazon is one of the best places to get it. You can't beat $10 a month for large dog flea protection. I also use one tube split into fifths (via syringe measurement) to give to my cats. Advantage II specifically is exactly the same product, in different dosages, for both dogs and cats. My 70-lb Lab gets a full 40 ml tube by herself, then the cats get 8 ml each and my brother-in-law's two ferrets get 4 ml each. I can cover 7 pets for $20 a month- a fantastic deal. The Advantage makes a noticeable difference in my pets' comfort- towards the end of the month, when it's wearing off, they begin to get itchy and uncomfortable. Once I reapply, that stops within a day or two, and they're happy and flea-free again all month. I have noticed that if our dog regularly gets into water (pool, beach, sprinklers), the Advantage wears off much quicker, despite claiming to be waterproof. That's understandable in a topical treatment, so we try to keep her out of water until the end of the application cycle, before a new treatment- then she gets to get wet to her heart's content! If you need to bathe your dog to kill fleas before applying, be sure to wait a day or two after the bath to give your dog's natural skin oils a chance to bounce back- it helps to distribute the medication. Be aware: this product is alcohol-based, and will evaporate quickly if left out in open air (we use a glass baby food jar to split the dosages in the syringe). It has also stripped the lacquer off the dining table when a few drops spilled while splitting doses, so try to avoid that too! Other than that, Advantage II is, in my opinion, the best topical flea control.
P**D
test before use some dogs alleric
worked on my dog for one season then i had to switch, irrated my dor the seconed patch, gave it to my nieghbor, dont know what happend kept col dry place.
D**G
Good product!
This works well for our pets! I have used it for years!
H**Y
Kills fleas well normally, but some seasons fleas are particular difficult to control. This is a bad flea year for my area!!!
I have used this product for years on my dogs & can normally go as long as up to 8 weeks between doses. I have noticed that on some years (2014 & 2011) that the fleas are particular difficult to control. I know it is not due to this product not being effective because I have treated my yard with 2 different products that normally work very well within a 10 day period & even those products have made very little difference in the fleas. I have treated my dogs at 9 days & repeated again at 13 days. I am also using natural flea shampoo & topical sprays with essential oils. The fleas do die within 12 hours, but by that time my dog with allergies is a mess due to bites before they die. I am now seeing primarily very tiny fleas which tells me that I am achieving some control over the adult fleas. I dislike giving doses that close together, but that is what the insert recommends (actually every 7 days until controlled) for heavy flea infestations. One of my dogs has terrible flea allergies. He has been miserable & has been on prednisone & benadryl for over a month. I don't even like for him to be outdoors because they are so bad. I have to pick fleas off both dogs every time they step outside. I don't have any carpet in my home so I know they are not living in my house. It just seems that some years the fleas are just almost impossible to control. I am in Savannah, Ga. Last summer, the fleas were no problem at all. I did not even treat my lawn. I only gave Advantage every 6-8 weeks. The summer of 2011 was also a bad flea year. I'm not sure what is the cause, probably something to do with the weather or maybe they just have cyclic bad years (who knows). I thought this would be a mild year for fleas because the winter was so cold, but that apparently is not true. I have learned that unfortunately on bad flea years it will take a few months to get the fleas under control even using multiple products. Nothing much else you can do, but suffer until they are under control!!...............Update: After treating my yard with 2 different products within a month & treating my dogs with 3 doses (once every 10 days), the fleas appear to finally be under control. No fleas for 3 days!!! Allergic dog is finally getting some relief. Hopefully, I can now only treat my dogs monthly since I have gotten the severe flea infestation under control. It just takes a while to break the flea life cycle if you have a severe infestation..............UPDATE...Fleas are finally under control. Have not had to re-apply for 4 weeks. Just had a small flea on my allergic dog. Will re-apply today. Once you break the flea life cycle this will control the fleas. I buy the large dog size package & draw out the dosage for each dog with a blunt tip syringe. This is more cost effective & I have found that I can control the fleas by using a smaller dosage for my 30lb dog with allergies. The size package for his weight is a 2.5ml dose (weight range 21-55 lbs). He only weighs 30lbs & the weight limit is a very broad range for his size. The next smaller size range (10 to 20 lbs) is 1.0 ml so at approximately 0.5ml per 10 lbs, I don't feel he needs the entire 2.5ml dose & I have found that he does not. I normally am able to give him only 1.5 to 2.0 ml which will work fine once the severe infestation is under control. I don't like having to give chemicals to my dog & the less the better. He also has skin problems & the Advantage does seem to flare up his skin problems, so less is better. I am also able to give my cat a dose if he happens to pick up an untreated flea (he is an inside cat, but he will occasionally sneak out if he can). The Advantage is the same ingredients for dogs & cats (also confirmed with my vet), but the Advantix is NOT. DO NOT give Advantix to cats!
W**Y
This is a great product, but it doesn't work on ticks
I buy the Extra Large for dogs and use it on my cats and dogs. My dogs are are @ 90 lbs. and they each get one 4.0 cc application. I use a syringe, (no needle) and put .08 cc on each of my cats monthly. The dose can also be adjusted if you have a small dog because the dose is configured by the animals weight. It's worth it to purchase a syringe and a tiny container if you are going to divide up the dose for your pets. Flea treatments have to be used consistently if you want to control flea. An adult female flea can lay up to 40 eggs a day and up to 5000 during their life cycle. The eggs fall off your pet and will end up in your carpet, couches, bed, cracks in wood floors, etc. and hatch anywhere from 2 week to a month. You can't treat your pet once and think you've conquered the problem. You also have to vacuum your home and car as well as your bedding. This is a great product, but it doesn't work on ticks. There are a ton of websites you can go to and read about getting rid of fleas and flea products. **Don't do this with Advantix, Frontline, or any other flea product--this is only for Advantage II. These are the doses for cats and dogs: Cats weighing 9 lbs and less: 0.4 cc Cats weighting 10 lbs or more: 0.8 cc Dogs that weigh 11 - 20 lbs: 1.0 cc Dogs weighting 21 - 55 lbs: 2.5 cc Dogs weighing over 55 lbs 4.0 cc
J**K
Reliable protection for my girl!
Finding an effective flea treatment for a large dog can be a challenge, but Advantage II has always been my go-to. This 4-month supply for dogs 55+ lbs is perfect for keeping my dog protected throughout the season. It’s easy to apply, waterproof, and I love that it kills fleas at all life stages—larvae and eggs included—so we don't have to deal with any re-infestations. My order was delivered right on time on May 8th, and it's such a relief to have peace of mind knowing he's covered. Highly recommend for any large breed owners!
B**Y
It's effective without being too potent
I've been using this for years. It works pretty good. It's becoming less and less effective as the fleas evolve to it. But right now it's still pretty effective.
Trustpilot
1 month ago
3 days ago