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🐕🦺 Elevate your pet’s calm game—because stress-free pets make happy homes!
Vetoquinol Zylkene is a veterinarian-recommended calming supplement for small dogs and cats, delivering 75mg of natural alpha-casozepine to reduce anxiety and promote relaxation without drowsiness. Its lactose-free, preservative-free formula supports sensitive stomachs and daily behavioral health, making it an essential ally for pets facing travel, vet visits, loud noises, or separation stress.

| Active Ingredients | Active Ingredients: Hydrolyzed Milk Protein (Bovine): 75 mg (providing alpha-casozepine) |
| Asin | B07S5KTWLQ |
| Best Sellers Rank | #3,381 in Pet Supplies (See Top 100 in Pet Supplies) #2 in Dog Relaxants |
| Brand Name | Vetoquinol |
| Customer Reviews | 4.1 4.1 out of 5 stars (3,511) 4.1 out of 5 stars |
| Dog Breed Size | Small |
| Flavor | Milk |
| Item Form | Capsule |
| Item Highlight | Non-Drowsy, Lactose-Free, Calming Supplement to Support Relaxation, Offers Stress and Aid Occasional Anxiety Relief in Pets |
| Manufacturer | Vetoquinol |
| Manufacturer Part Number | 424083 |
| Model Number | 424083 |
| Number Of Items | 1 |
| Product Benefits | Anxiety Relief,Promote Relaxation,Reduce Stress |
| Specific Uses For Product | anxiety, moving, stress, thunderstorms |
| Target Species | Dog |
| Unit Count | 30 Count |
User
recommended for bad habits and stressful situations with multi cats household
game changer for me and my cats
User
Decided to revisit this and try it out again
Update 2 months:This is absolutely necessary to keep the peace in my household. I have started to give her slightly more than 75mg, because it wasn’t working as well after a while but giving her 1 pill plus a little sprinkle from the second pill works great. She is just over the weight suggested for the 75mg.I tried to give it every other day but it just was not working as well as every day. We still smoosh it into a few pill pockets and make like a dough and then I pinch off treat size pieces and she loves it! She cries for it every morning and that is what she wants for breakfast lol. She’s now refusing wet food because this is what she wants.Update 7 days after initial review:I have been giving 1/2 of a 75mg capsule twice a day to my cat for 7 days straight now and she has not attacked my other cat in 7 days! We usually have stalking and attacking constantly so to go from constantly to none is very impressive! What I really like is that she still has her personality and does not seem drugged in any way. She just isn’t a psychopath stalker anymore 🤷🏻♀️. I plan on continuing the regimen and giving 1/2 to her twice a day. I started by sprinkling half a capsule on her wet food but she doesn’t eat all of it (she doesn’t mind the powder at all) so instead I have been buying pill pockets and I just knead it into the pill pocket like a dough and she eats it right up. This way she gets the full dose and I’m not wasting any.Initial review:My vet recommended that I try this before we put my cat on Prozac.I have two cats. My cats are not litter mates, they are both 6 years old and I adopted them one year apart. Pandora was the second cat I adopted and she has turned out to be a little psychopath. She constantly bullies and stalks and chases and attacks my other cat. It drives me insane and at times it’s extremely draining. I have tried very good quality lab tested CBD, and every kind of feliway spray and diffuser there is. Nothing works.I purchased this about 8 months ago and the first time I gave it to her she full on attacked my foot (not playing, it was very aggressive) and she has never done that before. So I have not given it to her again.Out of desperation, I am revisiting this option, after reading more about how to administer, I think she probably just needs more time to adjust.I sprinkled half of one capsule on top of about a tablespoon of wet food. She ate almost all of it right away.I purchased some pill pockets and I think I can smush the powder into them and feed it to her that way to ensure she gets as much of the product as possible without wasting any.She goes crazy for pill pockets! I’ll gladly update this review once we finish the bottle.Tonight was the first night we started it again and she walked around the house looking for something to get into for about 30 minutes (typical) and then laid down and went to sleep.
User
Takes the edge off with fewer side effects
I bought this as part of end of life care to help keep my old mini doxie calmer in his last month or so of CHF and it seemed to help. Then I started giving what was left to my new rescued mini doxie beagle mix to help him adjust to a new home. When it ran out he definitely was more glued to the door sniffing under it and baying at neighbors walking by in the hall, so I ordered it again and he’s chilled out. It says for over 11lbs to do 2 capsules, but I’ve found 1 capsule works well enough for 12-13lb dogs, but I also give L-theanine 2x a day.It’s a little more expensive than Prozac or Trazodone for dogs, but I like that it’s non drowsy and I don’t have to worry about seratonin syndrome or aggression which can be a risk for stacking the two drugs. Zyklene and L-theanine daily with Trazodone as needed seems safer and has worked for two dogs for me.
User
Helped my cat be less skittish and no more pee accidents
We have been giving this to our anxious cat for close to a year now. For a while, i couldnt tell if it worked... but after several months she is no longer peeing on anything. She is more cuddly and less skittish. So I would say it works.We open the capsule and mix it in with wet food ever morning.
User
Help for a price
Helpful for our kitty, but, as is the case for all animal care, pricey.
User
Decent product but the constant price increases force me to look for alternatives
I have a small terrier with allergies and anxiety. For her to be happy, I have to manage both. This product does a good job of relaxing her, though it is not the only thing I use. I do notice when I stop using it she is antsier, so I have chosen to continue the product. But the price continues to increase from expensive to untenable. I looked around for alternatives.The active ingredient is called Alpha-Casozepine, according to the label. So, in looking for products with this, it turns out that Lactium is a trademarked version of this. It was difficult to find a product with this alone. Ultimately, I found a Swanson Antistress human product that contained only this as an active ingredient. There are other products that have this ingredient along with other things that I didn't want. I'll see how this new product works once I receive it.Interestingly, Calmkeen, a product that markets itself as similar, has hydrolyzed milk protein as the active ingredient, but it does does not have the actual Alpha-Casozepine. I bought it to alternate with Zylkene, but it simply does not work as well for my dog. And the price, which is significantly cheaper than Zylkene, has continued to rise likely because Zylkene's has. Anyway, if money is no option, then Zylkene is an effective product. If you don't want to continue to pay chronic price increases, you may need to look for an alternative.
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